EPIDEMIOLOGICAL AND CLINICAL MANIFESTATIONS OF DENGUE IN DISTRICT PESHAWAR: A MULTI-CENTER STUDY

Authors

  • H SAADIA Institute of Zoological Sciences, University of Peshawar, Peshawar 25000, Pakistan
  • K NAWAZ Department of Chemical and Life Sciences, Qurtuba University of Science and Information Technology Peshawar, Peshawar 25000, Pakistan
  • K FATIMA Department of Zoology, Wildlife, and Fisheries, University of Agriculture, Faisalabad 38000, Pakistan
  • S KHAN School of Resources and Environmental Engineering, East China University of Science and Technology, Shanghai 200237, China
  • K SULTANA Medicinal Botanic Center, Pakistan Council of Scientific and Industrial Research (PCSIR) Laboratories Complex, Peshawar, 25000, Pakistan
  • IU HAQ Department of Allied Health Sciences, Iqra National University Peshawwar, 25000Peshawar, Pakistan
  • A ULLAH Rehman college of Allied Health sciences, Rehman Medical Institute Peshawar, 25000Peshawar, Pakistan
  • J ULLAH 6Department of Allied Health Sciences, Iqra National University Peshawwar, 25000Peshawar, Pakistan

DOI:

https://doi.org/10.54112/bbasr.v2025i1.93

Keywords:

Dengue, epidemiology, Prevalence, Clinical Manifestation

Abstract

Dengue is a tropical infection caused by dengue virus. The current study aimed to characterize epidemiological, laboratory markers, and clinical features of dengue disease. For this purpose data was collected from Khyber Teaching Hospital (KTH), Hayatabad Medical Complex (HMC), and Lady Reading Hospital (LRH) Peshawar. The data on clinical symptoms of patients was collected by filling out a questionnaire. The laboratory diagnosis was noted down from the Complete Blood Count Test of patients. In the present study in all 500 patients, the percentages of fever and body pain were 100% while headache was recorded in about 87% of patients. Among the laboratory diagnosis, 51% of males and 46.43% of females were recorded with normal blood pressure. Similarly, about 59% of male and 52% of female patients were recorded with platelet count below normal.  In the majority of male and female patients (94.8%) the normal red blood cell level was recorded. The hemoglobin (Hb) level in most male patients (82.7%) and females (78.5%) was recorded between 14-17.5g/dl which lies in a normal range of Hb. Out of 500, most of the patients (48%) suffered from dengue infection for 7 days. The study concluded that dengue infection does not have much influence on blood pressure, white blood cell level, red blood cell level, or hemoglobin level of patients and was recorded with their normal ranges. However, the platelet level of an individual decreases with dengue infection. Moreover, the study observed that those people who spent more time outdoors had more chances to get dengue infection.

Downloads

Download data is not yet available.

References

Ahmad, M. (2017). Climate and weather patterns in Peshawar: A detailed overview. Peshawar University Journal, 23(4), 56-68.

Ahmad, M., Iqbal, M., & Khan, A. (2011). Epidemiological analysis of gender distribution in dengue cases across six Asian countries. Journal of Tropical Medicine, 18(2), 123–128.

Ahmad, S., Khan, A., & Akbar, S. (2020). Dengue fever in Pakistan: Historical perspective and future challenges. Journal of Public Health, 42(4), e395–e402.

Ali, R. (2017). Geographical and historical significance of Peshawar. Pakistan Historical Review, 12(4), 45-56.

Ali, R., Malik, S., & Yasmin, F. (2013). Dengue fever in Pakistan: Gender-based epidemiology and clinical findings. Journal of Health Science, 6(4), 221–229.

Ali, S., & Khan, R. (2019). Seasonal climate variations in Peshawar and its impact on agriculture. Journal of Environmental Studies, 15(3), 120-134.

Anwar, S., Waseem, A., Khan, A., & Asif, M. (2019). Epidemiological analysis of dengue virus outbreaks in Pakistan. Journal of Medical Virology, 91(1), 120–128.

Bikangui, R., Moussavou, B., Yobo, C. M., Ndong, R. N., & Biyogo, F. S. (2022). Impact of urbanization on the spread of Aedes vectors and dengue virus transmission. Journal of Infectious Diseases and Epidemiology, 8(1), 1–8.

Bukhari, S. (2017). History and culture of Peshawar: A city of ancient significance. Peshawar University Press.

Chan, M., Johansson, M. A., & Wilder-Smith, A. (2008). Epidemiology and clinical features of dengue virus infections in Southeast Asia: A review of studies from the past decade. Journal of Clinical Virology, 41(2), 123–133.

Dalpadado, J., Amarasinghe, L. D., Senanayake, P. A., & Hapuarachchi, H. A. C. (2022). Ecological factors influencing the distribution of Aedes albopictus in dengue-endemic regions of Asia. International Journal of Mosquito Research, 9(2), 55–65.

Dehghani, R., & Kassiri, H. (2021). Epidemiological and clinical aspects of dengue fever: A review. Journal of Tropical Medicine, 2021, 9929763.

Deshwal, V., Kumar, A., & Sharma, R. (2014). Age group distribution and gender-based variation in dengue infections: A study from India. International Journal of Infectious Diseases, 20, 110–115.

Durrani, M., Bukhari, S. A., & Ali, A. (2014). Gender-based risk factors and age group distribution in dengue fever patients in Pakistan. Journal of Epidemiology & Global Health, 4(2), 121–126.

Eldigail, M., Sabir, M., & Haroon, M. (2018). Socio-demographic factors and their influence on the incidence of dengue fever in Pakistan: A case study. Journal of Social Science Research, 10(4), 45–52.

Gadhwal, A., Sharma, R., & Verma, R. (2016). Epidemiology of dengue fever: Gender differences in infection rates in South Asia. Journal of Clinical Epidemiology, 29(3), 211–217.

Gadhwal, S., Lim, P. K., & Raj, S. (2016). Epidemiological trends of dengue fever in Singapore: A gender-based study. Asian Pacific Journal of Tropical Medicine, 9(4), 320–325. https://doi.org/10.1016/j.apjtm.2016.03.015 DOI: https://doi.org/10.1016/j.apjtm.2016.03.015

Ghani, M., Javed, S., & Khan, M. (2017). Epidemiological analysis of dengue fever outbreaks in Pakistan: A gender-based perspective. Journal of Public Health and Epidemiology, 9(3), 39–46.

Guo, C., Zhou, Z., Wen, Z., Liu, Y., Zeng, C., Xiao, D., & Fan, J. (2017). Global epidemiology of dengue outbreaks in 1990–2015: A systematic review. International Journal of Infectious Diseases, 65, 1–13. DOI: https://doi.org/10.3389/fcimb.2017.00317

Gutiérrez-Bugallo, G., Piedra, L. A., Rodriguez, M., Bisset, J. A., Lourenço-de-Oliveira, R., Weaver, S. C., & Vega-Rúa, A. (2020). Vector-borne transmission and evolution of Zika virus. Nature Reviews Microbiology, 18(8), 451–464.

Hasan, A., Siddiqui, S., & Hussain, S. (2021). Epidemiological analysis of dengue fever in males and females: A study from Karachi, Pakistan. International Journal of Infectious Diseases, 35, 49–56.

Hasan, S., Malik, I., & Ghani, A. (2013). Prevalence and clinical manifestations of dengue fever in Pakistan. Tropical Disease Journal, 12(1), 53–59.

Hassan, M. (2020). Prevalence and clinical characteristics of dengue fever in a male-dominated population: A study from Karachi, Pakistan. Journal of Infection and Public Health, 13(4), 554–560.

Hegazi, M. A., Abdelmaksoud, N. M., & Zaki, M. M. (2020). Dengue virus serotypes: Evolution, pathogenesis, and future prospects. Journal of Virological Research, 96(4), 543–556.

Iqbal, H., Bukhari, S., & Shah, T. (2020). Peshawar's climate: A long-term analysis. Regional Climate Report, 8(2), 77-89.

Iqtadar, A., Khan, M. S., & Ali, S. (2017). Dengue infection and its clinical implications in Pakistan: A focus on gender disparities. Journal of Medical Sciences, 16(4), 202–209.

Jing, Q., & Wang, Q. (2019). Dengue: The fastest-spreading mosquito-borne viral disease. Infectious Diseases and Therapy, 8(4), 527–540.

Khalid, A., Siddiqui, R., & Imran, M. (2015). Gender distribution and severity of dengue fever in Pakistan: A nationwide survey. Journal of Infectious Diseases & Therapy, 4(2), 290–295.

Khan, A., & Ahmed, Z. (2018). Peshawar's location and strategic importance. Journal of Regional Studies, 11(2), 77-89.

Khan, A., Shah, T., & Ali, R. (2021). Population dynamics in Peshawar: Trends and projections. Peshawar Research Journal, 10(1), 55-60.

Khan, J., Khan, I., & Amin, I. (2017). Environmental and occupational risk factors of dengue fever in Peshawar, Pakistan. Journal of Environmental Health Research, 15(1), 118–124.

Khan, J., Khan, I., & Amin, I. (2017). Gender-based distribution and clinical presentation of dengue fever patients in Swat, Pakistan. Journal of Infectious Diseases & Therapy, 5(2), 333.

Khan, J., Khan, I., & Amin, I. (2017). Gender-based distribution and clinical presentation of dengue fever patients in Swat, Pakistan. Journal of Infectious Diseases & Therapy, 5(2), 333.

Khan, J., Khan, I., & Amin, I. (2018b). Comparative study of dengue fever incidence by gender and age in Peshawar, Pakistan. Journal of Infectious Diseases & Therapy, 6(1), 89.

Khan, M. A., Iqbal, Z., & Ali, S. (2018). Gender and age-based variation in the incidence of dengue fever in Pakistan. Asian Pacific Journal of Tropical Medicine, 11(4), 241–245.

Kimata, I. (2022). Comparison of febrile illnesses in Africa: Dengue, chikungunya, and malaria. Tropical Diseases, 32(4), 207–215.

Kolimenakis, A., Heinz, S., Wilson, M. L., Winkler, V., Dakouo, M., Stavros, K., & Konaté, L. (2021). The role of socioeconomic and environmental factors on the prevalence of dengue in West Africa. Acta Tropica, 217, 105861.

Mian, M. (2017). The climate of Khyber Pakhtunkhwa: Trends and projections for Peshawar. Environmental Monitoring and Assessment, 30(1), 89-101.

Mian, M. (2018). Peshawar in the Kushan Empire. Historical Journal of South Asia, 45(2), 89-102.

Narayanan, R., Sundararajan, V., & Kumar, V. (2003). Clinical manifestations of dengue fever: A study of hospitalized patients in India. Indian Journal of Medical Research, 118(4), 208–212.

Normile, D. (2013). Surprise dengue virus throws a spanner in disease control efforts. Science, 342(6157), 415. DOI: https://doi.org/10.1126/science.342.6157.415

Rai, M. A. (2011). Dengue fever in Pakistan: Epidemiology, challenges, and prevention strategies. Eastern Mediterranean Health Journal, 17(11), 975–980.

Rimal, B., Tiwari, S., & Shrestha, R. (2023). Emerging serotypes and trends of dengue virus in South Asia. Virology Journal, 20(1), 110.

Roy, R., & Bhattacharjee, S. (2021). Emergence of a novel dengue virus serotype and its implications for public health. Virology Journal, 18(1), 1–9.

Shah, T. (2018). Weather extremes and temperature trends in Peshawar. Weather & Climate Studies, 10(2), 45-60.

Shah, T., & Bukhari, S. (2016). Peshawar: A city at the crossroads of history and geography. Peshawar University Press.

Sirisena, P., Noordeen, F., & Kurukulasuriya, H. (2021). Co-circulation of multiple dengue virus serotypes and the risk of severe dengue outbreaks: A review of recent findings in South Asia. Journal of Infection in Developing Countries, 15(7), 905–912.

Suleman, M., Feroz, M., & Khan, S. (2017a). Epidemiology and gender distribution of dengue fever in Khyber Pakhtunkhwa, Pakistan. Journal of Infectious Diseases & Therapy, 5(3), 367–371.

Suleman, M., Feroz, M., & Khan, S. (2017b). Environmental and occupational risk factors of dengue infection in endemic regions. Journal of Environmental Health Research, 17(4), 251–259.

Tamura, T., Morita, K., & Kashiwagi, K. (2022). Antigenic variability of dengue virus serotypes and implications for vaccine development. Immunology and Cell Biology, 100(3), 276–284.

Villar, L., Dayan, G. H., Arredondo-García, J. L., Rivera, D. M., Cunha, R., Deseda, C., ... & for the CYD-TDV Dengue Vaccine Working Group. (2015). Efficacy of a tetravalent dengue vaccine in children in Latin America. New England Journal of Medicine, 372(2), 113–123. DOI: https://doi.org/10.1056/NEJMoa1411037

Wang, J., Luo, D., & Zhang, Y. (2022). Structure, function, and inhibition of the dengue virus RNA polymerase. Current Opinion in Virology, 57, 101282.

Wasim, M., Zahid, M., & Naeem, R. (2014). Analysis of dengue fever cases in Rawalpindi during 2013: A public health perspective. Pakistan Journal of Medical Research, 53(1), 12–16.

Wisanuvej, S., Thammavong, P., & Yodporn, S. (2021). Clinical and laboratory findings of dengue patients: A retrospective study from Thailand. Asian Journal of Tropical Medicine, 24(3), 230–236.

World Health Organization (WHO). (1997). Dengue hemorrhagic fever: Diagnosis, treatment, prevention and control (2nd ed.). World Health Organization.

World Health Organization. (2002). Dengue and dengue hemorrhagic fever. Fact Sheet No. 117. Geneva: World Health Organization. Retrieved from https://www.who.int/news-room/fact-sheets/detail/dengue-and-severe-dengue

World Health Organization. (2013). Dengue outbreak in Swat, Pakistan: Situation report. Geneva: WHO. Retrieved from https://www.who.int/publications

World Health Organization. (2019). Ten threats to global health in 2019. Geneva: World Health Organization. Retrieved from https://www.who.int/emergencies/ten-threats-to-global-health-in-2019

Wu, J., Xu, Z., Su, Y., Ma, X., Zhang, Y., & Zhao, W. (2022). Global distribution and environmental drivers of Aedes aegypti and Aedes albopictus. Nature Communications, 13(1), 621.

Yang, W., Liu, J., Wen, Z., & Guo, Z. (2021). Epidemiological trends of dengue virus infections in southeast Asia and the Americas. Tropical Medicine and International Health, 26(8), 976–983.

Yuan, Y., Li, Y., & Yang, Z. (2020). Impact of climate factors on mosquito-borne dengue epidemics in Pakistan: A time-series analysis. Environmental Research, 182, 109067.

Zafar, M., Aslam, M., & Ahmad, I. (2013). Epidemiological investigation of dengue fever outbreaks in Khyber Pakhtunkhwa, Pakistan. Journal of Infectious Diseases & Therapy, 5(2), 267.

Zubair, M., Qureshi, A., & Amin, R. (2016). Gender-based differences in the incidence of dengue fever in Pakistan: A study of six provinces. Pakistan Journal of Public Health, 6(2), 134–140.

Downloads

Published

2025-03-13

How to Cite

SAADIA, H., NAWAZ, K., FATIMA, K., KHAN, S., SULTANA, K., HAQ, I., ULLAH, A., & ULLAH, J. (2025). EPIDEMIOLOGICAL AND CLINICAL MANIFESTATIONS OF DENGUE IN DISTRICT PESHAWAR: A MULTI-CENTER STUDY. Bulletin of Biological and Allied Sciences Research, 2025(1), 93. https://doi.org/10.54112/bbasr.v2025i1.93

Most read articles by the same author(s)

1 2 > >>