DETECTION OF CLINICAL BIOMARKERS ASSOCIATED WITH HEPATO AND RENAL MANIFESTATIONS IN COVID-19 PATIENTS

A SAMAD; A WAHEED; A SHOUKAT; R AFRIDI; A BIBI; MI KHAN; M RABNAWAZ; T RIDA; A SHAH; T ZIA; J ULLAH

doi:10.54112/bbasr.v2024i1.84

Authors

A SAMAD Department of Health and Biological Sciences, Abasyn University Peshawar, 25000 Peshawar, Pakistan
A WAHEED Centre for Biotechnology and Microbiology (COBAM), University of Peshawar, Peshawar 25000, Pakistan
A SHOUKAT Department of Basic and Applied Sciences, Islamic International University Islamabad (IIUI), Islamabad, Pakistan
R AFRIDI Institute of Biotechnology and Genetic Engineering, Agriculture University Peshawar, Peshawar 25000, Pakistan
A BIBI Department of Health and Biological Sciences, Abasyn University Peshawar, 25000 Peshawar, Pakistan
MI KHAN Department of Statistics, Virtual University Peshawar, Peshawar 25000, Pakistan
M RABNAWAZ Department of Allied Health Sciences, Iqra National University (INU) Peshawar, 25000 Peshawar, Pakistan
T RIDA Department of Health and Biological Sciences, Abasyn University Peshawar, 25000 Peshawar, Pakistan
A SHAH Department of Health and Biological Sciences, Abasyn University Peshawar, 25000 Peshawar, Pakistan
T ZIA Cell development and Microbiology, Department of biological Sciences, Ohio University, Athens OH, United States of America
J ULLAH Department of Allied Health Sciences, Iqra National University (INU) Peshawar, 25000 Peshawar, Pakistan

DOI:

https://doi.org/10.54112/bbasr.v2024i1.84

Keywords:

Covid-19, hepato and renal, liver markers, CRP, ferritin

Abstract

The COVID-19 pandemic has spread in many countries worldwide, surpassing one million confirmed cases and resulting in deaths globally. Developing nations such as Pakistan face heightened vulnerability to such outbreaks due to limited healthcare infrastructure and resources. This study examines clinical biomarkers linked to hepatic and renal manifestations in COVID-19 patients in North Waziristan, recognizing the vulnerability of developing countries like Pakistan to such pandemics due to limited healthcare resources. Nasopharyngeal swabs were collected from 110 suspected COVID-19 patients visiting Dr. Azim Ullah clinic and DHQ Hospital North Waziristan, Miran Shah. Hematological, hepatic, renal, C-reactive protein (CRP), and ferritin markers were assessed. Most patients were male (75%), with varying age distributions. Abnormalities were observed in hematological parameters, liver enzymes, renal function markers, CRP, and ferritin levels. Significant correlations (p<0.001) were found among these markers. The study concludes that inflammatory, hematological, renal, and liver markers are associated with COVID-19 infection, with higher levels indicating severe disease. Continuous monitoring of these biomarkers may enhance patient outcomes and aid in predicting disease progression

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