ANTIVIRAL RESPONSE OF DRUGS USED AGAINST HBV PATIENTS OF KHYBER PAKHTUNKHWA, PAKISTAN

N HASSAN; FU AMIN; K BASHIR; M IRSHAD; S JAMIL; N MUNAWAR; H HAQQANI; H SHABIR; MA KHAN

doi:10.54112/bbasr.v2023i1.49

Authors

N HASSAN Department of Health and Biological Science, Abasyn University Peshawar, KP Pakistan
FU AMIN Department of Health and Biological Science, Abasyn University Peshawar, KP Pakistan/Division of Life Science, Center for Cancer Research and State Key Lab for Molecular Neuroscience, Hong Kong University of Science and Technology
K BASHIR Department of Health and Biological Science, Abasyn University Peshawar, KP Pakistan
M IRSHAD Department of Health and Biological Science, Abasyn University Peshawar, KP Pakistan
S JAMIL Department of Health and Biological Science, Abasyn University Peshawar, KP Pakistan
N MUNAWAR Department of Health and Biological Science, Abasyn University Peshawar, KP Pakistan
H HAQQANI Department of Health and Biological Science, Abasyn University Peshawar, KP Pakistan
H SHABIR Department of Health and Biological Science, Abasyn University Peshawar, KP Pakistan
MA KHAN Department of Medicine, Khyber Medical college, Peshawar Khyber Pakhtunkhwa, Pakistan

DOI:

https://doi.org/10.54112/bbasr.v2023i1.49

Keywords:

Hepatitis B virus, Entecavir, Tenofovir, Bilirubin, Creatinine, ALT

Abstract

Hepatitis B virus is an ample cause of end-stage liver diseases and hepatocellular carcinoma. Effective treatment in high-risk countries such as Pakistan can help delay or prevent these consequences.The existing study aims to evaluate the response rates of antiviral drugs tenofovir and entecavir (6-48 months) based on different clinical parameters. Sera collected from HBV patients (43) subjected to DNA extraction, followed by real-time PCR detection. Furthermore, ICT was performed to detect HBs-Ag and ELISA for HBe-Ag. Response rate after 6 months of tenofovir treatments showed 100% normal creatinine and ultrasound and ALT (50%) and while in the case of entecavir, each ALT and ultrasound normalization (66.7%), showed creatinine (100%). The fatty liver was reported 50% and 33.3% after tenofovir and entecavir treatment, respectively. The response after 12 months of treatment with tenofovir showed normalization of ALT and ultrasound (84.6%), bilirubin and creatinine normalization (92.3%), and fatty liver (15.4%). Whereas bilirubin and creatinine levels showed (100%) normal, ALT and ultrasound normalization (80%) with 20% of patients having congenital left lobe of the liver after entecavir. Patients profiles after 24 months of tenofovir treatment showed normal ALT and ultrasound (85.7%), bilirubin (100%), and renal impairment observed in patients (14.3%). The 24 months entecavir treatment showed significant improvement in various clinical parameters normalization with 100% such as ALT, bilirubin, and creatinine in all patients. The efficacy of entecavir showed a significant response as compared to Tenofovir. Furthermore, nucleoside/nucleotide analogues enhanced its efficacy with longer treatment duration.

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