CHEMOSENSITIZATION: A NEW HOPE FOR OVERCOMING FUNGICIDE RESISTANCE IN CROP PROTECTION

K TRIPATHI; R KUMAR; P KAUSHIK; NA SHAKIL

doi:10.64013/bbasr.v2026i1.125

Authors

K TRIPATHI ICAR-Indian Agricultural Research Institute, New Delhi-110012, India
R KUMAR ICAR-Indian Agricultural Research Institute, New Delhi-110012, India
P KAUSHIK ICAR-Indian Agricultural Research Institute, New Delhi-110012, India
NA SHAKIL ICAR-Indian Agricultural Research Institute, New Delhi-110012, India

DOI:

https://doi.org/10.64013/bbasr.v2026i1.125

Abstract

The chemical method of pest control is the most reliable in crop protection for high yield and better quality of produce. In agriculture more than 200 fungicides are in use and have different modes of action. The number of registered fungicides is based more on the above. New generation fungicides such as triazoles or azoles, methoxy acrylates group, etc., are used against phytopathogenic fungi and significantly control the most severe diseases. Despite multiple applications of these fungicides in the crop in the same growing season, they are needed for the management of these pathogens. But application at these doses promotes the development of resistance and is detrimental to the environment. That can make any fungicide costly as well as does not last very long for the farmers. Several trials have been done at higher doses, causing biomagnification as well as bioconcentration. which is also not sustainable from any point of view. So in search of different sustainable ways to overcome these resistance problems. One of the rational ways is to use chemosensitization, where natural compounds help to increase the antifungal activity of modern fungicides to solve these acute problems. It is the combination of synthetic or commercial fungicides with non- or marginal natural compounds where it synergistically increases the efficacy of the target fungicides. Generally, the target of a chemosensitizing agent differs from commercial or known fungicides in both biochemical and structural ways. Chemosensitization is eco-friendly in the way of reducing doses of fungicides. In this review, chemo-sensitization helps to cross the bottlenecks of resistant problems against modern fungicide groups when they are co-applied with natural metabolites or secondary plant metabolites. We must understand the problem and mechanism of resistance development in the fungus as well.

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